Mapping of cancer cell fuel pumps paves the way for new drugs

Apr. 28, 2013 ? For the first time, researchers at Karolinska Institutet in Sweden have managed to obtain detailed images of the way in which the transport protein GLUT transports sugars into cells. Since tumours are highly dependent on the transportation of nutrients in order to be able to grow rapidly, the researchers are hoping that the study published in the scientific magazine Nature Structural & Molecular Biology will form the basis for new strategies to fight cancer cells.

In order to be able to fuel their rapid growth, cancer tumours depend on transporter proteins to work at high speed to introduce sugars and other nutrients that are required for the cell's metabolism. One possible treatment strategy would therefore be to block some of the transporters in the cell membrane which operate as fuel pumps, thus starving out and killing the cancer cells.

One important group of membrane transporters is the GLUT family, which introduces glucose and other sugars into the cell. Glucose is one of the most important energy sources for cancer cells and GLUT transporters have been shown to play a key role in tumour growth in many different types of cancer.

In the current study, researchers from Karolinska Institutet have performed a detailed study of the way in which suger transport is executed by the protein XylE, from the Escherichia colibacterium, whose function and structure is very similar to GLUT transporters in humans. For the first time, the researchers have described the way in which the protein's structure changes between two different conformations when it binds and transports a sugar molecule.

"In showing details of the molecular structure of the region that bind the sugar, our study opens up the opportunities to more efficiently develop new substances that may inhibit GLUT transporters," says P?r Nordlund at the Department of Medical Biochemistry and Biophysics, one of the researchers behind the study. "Information on the structure of the transport protein facilitates the development of better drugs in a shorter time. Such GLUT inhibitors could potentially be used to treat cancer in the future."

The study may be of significance not just to cancer research but also in the field of diabetes. GLUT plays a key role in diabetes since insulin works by activating the uptake of glucose from the blood by means of GLUT transporters in the cell membrane.

GLUT and the studied XylE transporter belong to the very large group of metabolite transporters called the Major Facilitator Superfamily (MFS), which is important in many diseases and for the uptake of medicines in cells.

"Many aspects concerning molecular mechanisms for the function of GLUT transporters are probably common to many members of the MFS family, which are involved in a broad spectrum of diseases in addition to cancer and diabetes," says P?r Nordlund.

As well as membrane transporters, which have undergone in-depth analysis in the current study, many different membrane proteins pass through the surface membrane of the cells. Their significance to the cell function and the development of drugs has been noted before, not least through the Nobel Prizes that were awarded to researchers who used mechanistic and structural studies to map the function of two other major membrane protein families, G-protein-coupled receptors and ion channels.

The current study has been financed by grants from the Swedish Research Council, the Swedish Cancer Society, the European Molecular Biology Organization (EMBO) and The Danish Council for Independent Research.

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The above story is reprinted from materials provided by Karolinska Institutet, via AlphaGalileo.

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Journal Reference:

1. Esben M Quistgaard, Christian L?w, Per Moberg, Lionel Tr?saugues, P?r Nordlund. Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters. Nature Structural & Molecular Biology, 2013; DOI: 10.1038/nsmb.2569

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/YpfcBJy_z0w/130428144853.htm

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Justin Bieber and Selena Gomez: Cuddling, Shirtless, SEXY in New Photo!

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Early Earth's chlorine blown away by giant impacts

Element has long puzzled scientists because modern levels are so low

By Erin Wayman

Web edition: April 24, 2013

Earthlings may owe a debt of gratitude to the enormous miniplanets that smashed into the planet in its youth. Such collisions might have knocked away much of the supply of chlorine concentrated on the planet?s surface, geochemists propose. Had that loss not occurred, the world?s oceans would have been too salty for complex life to thrive, they suggest.

The scenario may explain why Mars, which suffered fewer large impacts, may have more than twice as much chlorine as Earth does, the researchers report April 16 in Earth and Planetary Science Letters.

?The story seems to hang together pretty well,? says James Brenan, a geologist at the University of Toronto who wasn?t involved in the study. ?Life, probably over a fairly long time, might have been able to adapt to this environment, though certainly things would be different than today.?

One snag is that the idea is ?a very difficult thing to test,? says geochemist Ray Burgess of the University of Manchester in England.

The composition of ancient meteorites, which are remnants of the raw material that built the planets, indicates that Earth should have 10 times as much chlorine as it does. The missing chlorine has perplexed scientists for decades. In 1995, geochemist William McDonough suggested that chlorine was dragged to Earth?s center by iron, nickel and other metals that formed the planet?s core.

Normally, chlorine and other elements known as halogens don?t readily dissolve in metals or often combine with other elements to form minerals found in rocks. But perhaps under the intense heat and pressure of the core, chlorine might have become more willing to mix with metal. ?I wasn?t happy with putting it in the core,? says McDonough, of the University of Maryland in College Park. But he didn?t know what else to do with it. ?I was scratching my head,? he says.

The new work suggests that, in fact, the core is not where chlorine went. In lab tests, Zachary Sharp of the University of New Mexico in Albuquerque and David Draper of the NASA Johnson Space Center in Houston approximated the conditions of the core and observed chlorine?s behavior. They added iron metal, rocks typical of the mantle and a chlorine compound to a capsule heated to 1900? Celsius under pressures about 80,000 times higher than Earth?s atmospheric pressure. The result: Chlorine still didn?t dissolve in iron. That means chlorine probably isn?t hiding out in the core, Sharp says.

So he and Draper looked elsewhere for a solution. After ruling out the possibility that Earth never accumulated chlorine in the first place, the pair concluded that the incipient Earth rammed into giant planetary bodies more than 4 billion years ago and the repeated impacts blew the element away.

The explanation hinges on the peculiarity of chlorine. Unlike elements that mostly end up in rocks and metals, most of Earth?s chlorine is in salt deposits and brines or dissolved in the ocean. Because the element is concentrated on the surface, giant impacts in the past would have stripped away a good chunk of Earth?s chlorine supply, Sharp and Draper say.

Had the early impacts not happened, Sharp says, ?the Earth would have been a halogen-poisoned planet.? The oceans would be as salty as the Dead Sea, and high salinity would reduce precipitation. With less rain, there would be less erosion on land and fewer nutrients washing into the sea. In such a world, he says, ?it would be much more difficult for [complex] life to evolve.?

McDonough acknowledges that the new work disproves the idea that chlorine is trapped in the core. However, he?s not yet convinced that cosmic crashes removed the element. Even with the massive collision that created the moon, the pull of gravity returned to Earth most of the material that had been kicked into space, he says. ?But I don?t have a better idea.?

To strengthen the argument, planetary geochemist Mikhail Zolotov of Arizona State University in Tempe suggests that the team develop simulations to assess how impacts could have affected elements in the young Earth?s atmosphere, oceans and crust. The team could also investigate whether other elements preferentially found on the surface are also lower than expected. ?

Source: http://www.sciencenews.org/view/generic/id/349930/title/Early_Earths_chlorine_blown_away_by_giant_impacts

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Tech company wants to launch ?space harpoon? to clean up debris

(Releads, adds Sheikh Mohammed's comments, Dubai dateline) DUBAI/LONDON, April 24 (Reuters) - Godolphin are to close the Newmarket stable of trainer Mahmood Al Zarooni while dope tests are carried out on all racehorses in his care after 11 tested positive for steroids, Dubai's ruler Sheikh Mohammed bin Rashid al-Maktoum said on Wednesday. "There can be no excuse for any deliberate violation," Sheikh Mohammed, also Prime Minister of the United Arab Emirates, said in a statement sent to Reuters. ...

Source: http://news.yahoo.com/blogs/sideshow/tech-company-wants-launch-space-harpoon-clean-debris-165233213.html

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High score: Man busted with pot-stuffed Pac-Man arcade game

Yannick LeJacq , NBC News contributor ? ? ? 3 hrs.

Video games and marijuana may have a rich shared history, but the two came together in an unexpected combination last week in Orangeburg, S.C., when local and federal authorities apprehended a man for smuggling 55 pounds of marijuana that had been stashed inside an arcade cabinet. A Pac-Man arcade, no less.

Authorities first arrested Luis Tyler on April 16 following an undercover investigation, Keisa Gunby, director of media relations for Orangeburg County Sheriff's Office, told NBC News.

"We knew that he was going to be receiving this video game and it was going to have narcotics in it, so we did a traffic stop before he was able to get where he was going with it," Gunby said.

Gunby said she couldn't remember another case involving such a machine, and told us that the Pac-Man cabinet was so tightly packed with pot, it was inoperable as a game console.

"It can't be a functional machine with that much marijuana inside," Gunby said. "It was never going to operate as intended."

While Tyler was apprehended last Tuesday and South Carolina Judge Derrick Dash subsequently set bond at $75,000 the following day, Sheriff Leroy Ravenell didn't announce the bust until Saturday, April 20. Also known as "4/20," that day is widely observed by North American pot smokers as a holiday.

The timing was a sheer coincidence, said Gunby, attributing the delay to remaining questions concerning Tyler's prosecution.

"We are still considering whether he's going to face federal charges or state charges," Gunby said.

The department did make use of the gaming angle, however.

"Our efforts to make Orangeburg safe will not stop," Ravenell is quoted as saying in a press release. "We ... will continue to investigate the criminals in our community and make arrests. You may be looking for a high score but what you'll get is game over!"

? via Kotaku

Yannick LeJacq is a contributing writer for NBC News who has also covered games for Kill Screen, The Wall Street Journal and The Atlantic. You can follow him on Twitter at @YannickLeJacq and reach him by email at ylejacq@gmail.com.

Source: http://feeds.nbcnews.com/c/35002/f/653377/s/2b1490fe/l/0L0Snbcnews0N0Ctechnology0Cingame0Chigh0Escore0Eman0Ebusted0Epot0Estuffed0Epac0Eman0Earcade0Egame0E6C956630A6/story01.htm

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Antares Rocket Launch Is A Success, In Test Of Orbital Supply Vehicle

The Antares rocket sits ready, moments before launch at NASA's Wallops Flight Facility.

NASA TV

The Antares rocket sits ready, moments before launch at NASA's Wallops Flight Facility.

NASA TV

The Antares rocket launch is back on for 5 p.m. ET Sunday afternoon, as engineers and spectators look for the rocket to lift off from a launch pad at NASA's Wallops Flight Facility. A check of all systems at 10 minutes before its launch was positive.

Update at 5:10 p.m. ET. Orbit Achieved, Payload Separated:

Antares moved smoothly through its stages and achieved orbit, drawing applause from engineers watching in the control room. Soon after, it delivered its practice payload into orbit around the Earth. The test mission has about eight more minutes remaining.

Update at 5:02 p.m. ET. Liftoff Is A Success:

The Antares rocket soared above Wallops Island Sunday afternoon. Just before the engines were throttled down in Stage 1, the vehicle was traveling at more than 7,000 miles per hour. Our original post continues:

The mission had been postponed twice this week, after a connecting cable came loose on Wednesday and unfavorable winds forced a one-day delay on Saturday. Officials believe the launch may be visible from sites all along the eastern U.S. coast.

Around 3:30 p.m. ET Sunday, the rocket was approved for launch and fueling of the vehicle began, NASA reported.

The NASA facility is located just behind the beach on Wallops Island on Virginia's Eastern Shore. Antares is a product of a joint development project between NASA and Orbital Sciences Corp., based in Virginia.

As NPR's Geoff Brumfiel reported Wednesday, a successful test would eventually make Orbital "the second private company after California's SpaceX to dock with the space station."

Source: http://www.npr.org/blogs/thetwo-way/2013/04/21/178289293/antares-rocket-launch-is-a-go-in-test-of-space-station-supply-vehicle?ft=1&f=1007

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?Well I didn?t vote for you!? ?You don?t vote for kings!? ?Well how?d you become king, then?? (Unqualified Offerings)

Share With Friends: | | Politics - Top Stories Stories, News Feeds and News via Feedzilla.

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Insight: Pakistan cleric tries hand at politics

By Michael Georgy

JHANG, Pakistan (Reuters) - When Maulana Ahmed Ludhianvi greets supporters on the Pakistan election trail, he opens his pitch with the kind of promises to the poor that any other politician might make.

But behind the reassuring rhetoric lies what his opponents believe is a dangerous agenda - to gain a foothold in parliament and further his designs to oppress Pakistan's Shi'ite minority.

Ludhianvi, a radical Sunni cleric, is a hate figure for Shi'ites who accuse him of devoting his decades-long career to fomenting an escalating campaign of gun attacks and suicide bombings targeting their community.

The prospect that he might win a place in the political mainstream at the May 11 vote horrifies Shi'ites who fear his presence in parliament will give him a much stronger platform to strike out at the sect.

And it looks like Ludhianvi may have a better shot than at the last election in 2008 when he came second. His main rival has been barred from the race and a Reuters visit to his constituency of Jhang, in the heart of populous Punjab province, found no shortage of supporters.

"I cannot bring any change if I am sitting as a layman outside parliament," Ludhianvi, flanked by bodyguards, said in an interview. "If I get into parliament, everyone will be listening to what we want."

As he toured Jhang, which served as the cradle of sectarian extremist groups in the 1980s, people in one village after another emerged from their homes to shower him with rose petals.

"If I get into parliament, I will be able to save this entire country from bloodshed," said Ludhianvi, who wears a thick beard and an embroidered skull cap and projects a commanding presence.

The election is seen as a milestone for Pakistan's fragile democracy, marking the first time a civilian government has completed a full term in a country which a long history of military meddling in politics.

Western powers are hoping the polls might deliver a government capable of grappling with huge domestic challenges and helping the United States bring the Afghan Taliban to the negotiating table ahead of a NATO pullout in 2014.

Any triumph by Ludhianvi at the polls could be read as a sign that sectarianism - now seen as a top security threat - has made a troubling new in-road into the political sphere, which could further polarize the nuclear-armed country.

Ludhianvi was a leader of Sipah-e-Sahaba, a sectarian Sunni group which emerged in Jhang in the mid-1980s with the support of Pakistani intelligence and which has since been linked to hundreds of killings of Shi'ites.

The group's offshoot, Lashkar-e-Jhangvi (LeJ), evolved into one of Pakistan's most feared militant groups and has claimed responsibility for many attacks on Shi'ites, including a series of bombings that killed almost 200 people in the southwestern city of Quetta this year.

Police in Karachi, the commercial capital, suspect LeJ or similar groups are behind a wave of gun attacks on Shi'ites.

Pakistan banned Sipah-e-Sahaba in 2001 under pressure from the United States to crack down on militancy but the group changed its name to Ahle Sunnat Wal Jamat (ASWJ), which Ludhianvi heads.

Pakistan's sectarian fringe has long been plagued by divisions which make it hard to determine what role individual leaders play. But security officials see Ludhianvi as a member of a core group of ideologues whose anti-Shi'ite views have served as a source of inspiration for militants, though he denies any role in violence.

SUNNI-SHI'ITE DIVIDE

The military has in the past quietly supported Islamist politicians and parties in the interest of its own political agenda but it is not clear what stand the military-run security agencies that watch domestic politics are taking this time.

The army chief, General Ashfaq Kayani, has avoided the overt meddling in politics of many of his predecessors and repeatedly insisted the election must be free and fair.

The schism between Sunnis and Shi'ites developed after the Prophet Muhammad died in 632 when his followers could not agree on a successor.

Emotions over the issue have boiled in modern times and even pushed some countries to the brink of civil war. Pakistan is nowhere close to that, but security officials say groups like the LeJ and Sipah-e-Sahaba are stepping up their bloody campaign to persecute Shi'ites and are destabilizing the country.

These days, Ludhianvi is careful to portray himself as a man of peace and is waging a populist campaign to capitalize on resentment of Shi'ite landowners. Coming himself from a modest background, he has vowed to build schools, hospitals and roads.

"This is a tribal area which was ruled by a few rich people who used to treat the poor people like slaves," said Ludhianvi.

"There is no education system or schools for girls and boys. Nobody even tries to build schools or colleges."

But other senior members of his ASWJ party are more vocal about their desire to restrict the rights of Shi'ites.

Aurangzeb Farooqi, head of the party in Karachi, told Reuters in January that Shi'ites should be barred from holding important public office and their public religious activities should be restricted. Farooqi is also running for a seat in the national assembly.

In Jhang, Ludhianvi's blend of populism and sectarianism has earned him considerable grassroots appeal. He won 45,000 votes at the 2008 election, placing him second to Sheikh Waqas who won with 52,000 votes.

But Waqas has been barred from this election on the grounds that he had presented a fake education certificate, raising Ludhianvi's chances of victory.

Politicians are taking note. Rather than making alliances with big businessmen or going door-to-door for votes, aspiring office holders like Azad Ansari, who is in the wool industry, are rallying behind Ludhianvi.

Ansari once served in the secular PML-N but now hopes Ludhianvi can help him make a mark in politics.

"I will get more popular if I join him," Ansari said.

Such sentiment has fostered a perception that leaders of the PML-N party, which controls Punjab, have deliberately been soft on sectarian groups for fear of alienating potential voters.

These suspicions were compounded when Rana Sanaullah, Punjab's law minister and a PML-N stalwart, campaigned alongside Ludhianvi at a by-election rally in Jhang in 2010.

The spectacle of Ludhianvi reinventing himself sends chills through the Shi'ite community, which may make up to 20 percent of the population, though some estimates put the number lower.

"What can Ludhianvi do? He will do nothing but spread terrorism," said Raza Hussain, a resident of a Shi'ite neighborhood of Jhang.

Some fear that a victory for Ludhianvi and other hardliners at the polls will provide a veneer of political cover for violent sectarian extremists.

"This could be very dangerous," said Amir Rana, an expert on Pakistani militancy. "This would give all of their activities political legitimacy."

But some security officials argue that bringing leaders like Ludhianvi into conventional politics may be a way to weaken the sectarian threat by isolating the most violent elements.

Conscious of the need to project a respectable image, Ludhianvi is careful to avoid the kind of inflammatory rhetoric favored by many in his party.

But the presence of young men wearing headbands with the symbols of banned anti-Shi'ite groups, who hung on Ludhianvi's every word during his whistle-stop tour, keeps Shi'ites on edge.

"He has done nothing for Jhang except terrorism," said Sheikh Hussain, a businessman. "They should be stopped."

(Editing by Nick Macfie)

Source: http://news.yahoo.com/insight-pakistan-cleric-tries-hand-politics-013733217.html

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Coal Under Threat by Low Natural Gas Prices; Will This Be the End ...

Friday, April 19th, 2013
By Mitchell Clark, B.Comm. for Profit Confidential

Coal is a gigantic problem.

Because 40% or so of total U.S. railroad tonnage is coal?the most important commodity for railroad stocks?the railroad sector is under threat by low natural gas prices.

According to the Association of American Railroads (AAR), the shipping of coal is responsible for about one in five railroad jobs.

One of the first railroad stocks to report its earnings this season was CSX Corporation (NYSE/CSX), based in Jacksonville, Florida. CSX?s numbers were flat, but it beat consensus.

CSX reported first-quarter revenues of $3.0 billion, with growth in merchandise, intermodal, and other sales offsetting a decline in coal shipments.

Earnings were a record $459 million, or $0.45 per share, compared to $449 million, or $0.43 per share. The company increased its quarterly dividend by seven percent and announced a new $1.0-billion share buyback program.

CSX said that it expects average annual earnings-per-share (EPS) growth of 10%?15% starting from the end of this year to 2015 (a positive). Earnings for fiscal 2013 are expected to be flat or down compared to 2012 (a negative,?and below the previous average earnings estimate if that?s meaningful).

Among railroad stocks, CSX is less than half the value of Union Pacific Corporation (NYSE/UNP), which is my benchmark stock for the group.

The AAR releases a lot of statistics that are very useful, even outside the universe of railroad stocks. In 2012, railroads delivered 171,000 carloads of oil and petroleum products for a gain of 46% over 2011. This was less than the trade group previously expected.

According to the U.S. Energy Information Administration, U.S. crude oil production increased by a record 780,000 barrels per day in 2012. About 90% of this oil was transported by pipeline.

This agency also reported that railcar loadings of coal were down about 726,000 carloads, nearly 11%, to just over six million carloads in 2012. This decline is an ongoing issue for railroad stocks.

Still, the group has been very good at maintaining its earnings in light of declining shipments of coal. Railroad stocks are cyclical, but they?ve done very well to create more stability in their businesses. (See ?Keeping It Rolling?U.S. Energy Boom Good News for Railroad Stocks.?)

CSX?s dividend boost was welcome news, and so was its earnings stability. The stock is currently yielding about 2.3%. The new dividend is $0.15 per share, payable on June 14 to shareholders of record on May 31.

The fact that CSX was able to do such a good job controlling costs is an important metric for shareholders. The company reported that it significantly reduced its materials and supplies expenses, while fuel costs were flat with the comparable quarter. Coal shipment revenues were down 13% to $832 million.

I continue to like railroad stocks and the industry as a whole. As more earnings are reported, it?s worth perusing their FORM 10-Qs (quarterly reports mandated by the Securities and Exchange Commission). The shipment of goods is an excellent barometer for the U.S. economy. Coal won?t kill the railroads.

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Source: http://www.profitconfidential.com/stock-market/coal-under-threat-by-low-natural-gas-prices-will-this-be-the-end-for-railroad-stocks/

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Boehner, Pelosi Hint at Next Showdowns in Congress

Boehner, Pelosi Hint at Next Showdowns in Congress

After a "rough" week across the country, House Speaker John Boehner and Minority Leader Nancy Pelosi both addressed tragedy and strategy in their weekly news conferences today, offering their condolences to those affected by the Boston Marathon bombings and the West, Texas, explosion.

"Words alone cannot console the loved ones, but we will do what we can to care for them," Pelosi, D-Calif., said. "With the investigation ongoing, we will make sure that justice is done."

"Our hearts go out to the victims and the people of Boston," Boehner, R-Ohio, added. "[I'm] glad the president's up there today, and I add my prayers to his."

As the investigations in Boston and Texas proceed, inside the beltway Congress continues battling over a series of legislative showdowns.

Pelosi and her leadership team fired off a letter today to the speaker demanding that he appoint conferees to settle differences over the House and Senate-passed budgets.

"Right now the focus is on adopting a budget that reflects our country's values, creates jobs and strengthens the middle class," she said. "The Senate has passed its budget bill?and we're overdue; April 15 was the deadline for us having a budget for a conference report."

When asked whether he intends to comply with Pelosi's request, Boehner encouraged bipartisan informal conversations to continue between House Budget Chairman Paul Ryan and Senate Budget Chairwoman Patty Murray. The speaker predicted that the Democrats' approach would only lead to further political warfare because under House rules, if conferees fail to reach an agreement within 20 legislative days, the minority is able to make procedural motions to score political points.

"The minority has the right to offer motions to instruct, which become politically motivated bombs that?show up on the House floor," Boehner said. "We're following what I would describe as regular order. These informal conversations are underway, and that's the way it should work."

Both Pelosi and Boehner also addressed ongoing immigration reform, and congratulated the Gang of Eight on creating a bipartisan compromise.

"I want to congratulate the Senate Gang of Eight for coming forward with their bill," Boehner said. "I'm sure there's parts of it I would agree with, parts that I would disagree with, but the fact is that they've worked together in a bipartisan fashion to craft this bill."

Pelosi echoed the speaker's sentiments, and admitted that while the bill was commendable, it is not a perfect agreement for either party.

"I feel very confident about how we go forward on the immigration bill. I commend the eight Senators for the work that they did," she said. "Of course, it's a compromise. Would I change things? Of course, but I do think that that's what a compromise is about."

Boehner also noted that reaching compromise legislation among a small group of members does not necessarily prepare every other lawmaker to act on the issue.

"You have to remember, about three-fourths of members of Congress have never dealt with the issue of immigration," he said. "There's a big learning curve that the members are going to have to go through."

Also Read

Source: http://news.yahoo.com/boehner-pelosi-hint-next-showdowns-congress-183635172--abc-news-politics.html

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Apple confirms it keeps Siri data for up to two years (update: Google too)

It's no secret that Apple hangs onto your Siri data for some length of time (as other companies so with search data and the like), but it hasn't been clear exactly how long it keeps that data sitting on its servers. Wired has now cleared that up somewhat, though, hearing from Apple spokesperson Trudy Muller that the company "may keep anonymized Siri data for up to two years." That word follows another report from Wired yesterday that raised concerns about the issue. As Muller notes, the data is immediately deleted if a user turns Siri off at any time, and it's anonymized from the start; neither your Apple ID or email address are stored with a data, but rather a randomly generated number that represents the user and becomes associated with the voice files. That number then gets disassociated from voice clips after six months, but Apple still hangs onto the files for another 18 months for what's described as testing and product improvement purposes.

Update: The Financial Times has confirmed with Google that it, too, keeps your voice search data for up to two years. Google itself has previously detailed how it handles that data, including the added measures put in place when a user opts-in for personalized voice recognition; in that case, electronic keys linked to your account are generated that Google says are "designed to be accessed by machines, not people."

Filed under: Cellphones, Mobile, Apple

Comments

Source: Wired

Source: http://www.engadget.com/2013/04/19/apple-siri-data-two-years/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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China's ZTE says it basically dropped Iran business

By Jason Subler

BEIJING (Reuters) - ZTE Corp, China's second-largest telecoms equipment maker, has essentially stopped doing business in Iran after a U.S. investigation into alleged sales of embargoed equipment, the company's chairman told Reuters on Thursday.

ZTE said in March 2012 that it would curtail business in Iran following a report by Reuters that it sold Iran's largest telecoms firm a powerful surveillance system capable of monitoring telephone and Internet communications. The company is now facing a U.S. criminal investigation over the issue.

"We've basically stopped. We have to continue to service the products we had sold before - we have no choice," Hou Weigui said in an interview in Beijing. "We maintain communication with them to enable locals to carry out maintenance."

Hou's disclosure is the first public acknowledgement of how deeply the scrutiny has affected the company.

While he declined to give details on the amount of business ZTE had done in Iran before, Hou said the compensation it had to pay clients there for breaking contracts, and the fact that it had to halt some shipments even after equipment had been manufactured, were important reasons for the company's first-ever annual loss in 2012, of 2.84 billion yuan ($460.1 million).

Losses in Europe were also a big factor in the poor performance in 2012, he said.

"UNFAIR"

"I think we've really been treated unjustly on this issue. Others are selling the same things, and we weren't even selling the most," Hou said. "Now we face these restrictions, and others in the industry aren't facing any restrictions - they're all still selling. This is a bit unfair."

Hou said local rival Huawei Technologies Co Ltd was still doing business in Iran, but he declined to elaborate.

"We are not in a position to comment on what Huawei and others in the industry are doing. But in any case, they are still involved in the market. But we have stopped," Hou said.

Huawei, in response to a Reuters query on Thursday, repeated a statement it issued in late 2011 that it would no longer seek new customers in Iran and would limit business activity with existing ones.

Hou also said that U.S. moves to restrict sales of Chinese information technology equipment, which affect both ZTE and Huawei, were not fair.

A new U.S. law signed by President Barack Obama in March restricts government purchases of Chinese information technology out of security concerns, and a Congressional committee last October recommended to the U.S. government that Huawei and ZTE should be kept from the U.S. market, and told U.S. companies to stop doing business with both firms.

Hou said ZTE had some communication with the U.S. government on the issues, but he was pessimistic about the possibility of the company being able to change perceptions among lawmakers or the public. In the meantime, ZTE would focus primarily on the handset business in the United States, he said.

"Relying on a company to solve this is far from enough. This is actually an issue of how the two governments approach bilateral trade in high-tech goods," Hou said.

($1 = 6.1723 Chinese yuan)

(Additional reporting by Xiaoyi Shao and Anne Marie Roantree; Editing by Emily Kaiser and Ian Geoghegan)

Source: http://news.yahoo.com/chinas-zte-says-basically-dropped-iran-business-080519218.html

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Lotus driver Romain Grosjean insists they are working hard to make ...

Lotus driver Romain Grosjean insists they are working hard to make improvements ? Formula 1 news

Lotus driver Romain Grosjean has said that he is working hard with his engineers to make improvements in their car to attain better results in the season ahead.

Grosjean took a struggling start to this season as he could only score one point in the season opener with his 10^th place finish after setting off from 8^th grid slot. Later, he delivered a convincing performance in the Malaysian Grand Prix, but could only secure 6^th place finish after taking a start from 11^th grid position. Then, he came 9^th in the Chinese GP after qualifying for 6^th grid position.

On the other hand, his teammate, Kimi Raikkonen has performed tremendously well in the first three rounds of the season. He claimed an impressive victory in the Australian GP and secured an incredible second podium finish in the third race at Shanghai International Circuit in China. The Finn is currently standing at second place in this year?s drivers? championship. Besides, he is ahead of Fernando Alonso of Ferrari and behind Sebastian Vettel of Red Bull Racing.

The French driver has said that he is feeling a little bit frustrated because he has not been able to make the most out of his car in the season until now.

?I would be lying if I said the car is exactly where I want it and we are having quite an adventure to get the setup and feeling from the car how we want it,? Grosjean said. ?This is very frustrating for a driver, as you want your car to be obedient.?

Nonetheless, he expressed that they are trying their best to improve the pace of their car in order to compete well with their rivals. He also said that he is working hard with his race engineers to enhance his pace so as to score competitive points for his team in the forthcoming races.

?Certainly, we're not the only team who are having a difficult time early in the season, but it's something we really want to get on top of as quickly as possible. I'm spending a lot of time with my engineers and we're all working hard to make improvements,? he added.

Source: http://blogs.bettor.com/Lotus-driver-Romain-Grosjean-insists-they-are-working-hard-to-make-improvements-Formula-1-news-a214503

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Green Cars Showcased In Sacramento At Green California Summit ...

Sacramento will be the host of hybrid cars, EVs and many new green technologies as the Green California Summit and Exposition takes hold of the Californian city.

On Thursday and Friday, State and Consumer Services Agency Secretary, Anna Caballero, will participate as co-chair of the 7^th annual Green California Summit and Exposition at Sacramento?s Convention Center.

Caballero oversees the Building Standards Commission and Department of General Services, two departments heavily involved in green building codes and technology innovation.

?California?s environmental policies and programs are setting the pace for efforts around the U.S. and the world,? said State and Consumer Services Agency Secretary, Anna Caballero. ?If you want to know what?s new, what?s working, and what?s coming, you can?t miss the Green California Summit.?

The organizers said this year?s summit expo features a number of green products and services. The public can get a hands-on look at the latest hybrid or zero-emission vehicles, new building materials, energy efficient lighting, and technologies for onsite power generation.

In addition, for the first time this year, the public can also test drive the latest electric vehicles.

Keynote speakers Jane Long, chair of the California Council on Science and Technology?s ?California?s Energy Future? project and Greg Kats, an internationally recognized innovator in energy efficiency, renewable energy, green buildings and the transition to a low-carbon economy, will demonstrate how sustainability and green technology can go hand in hand with human and economic prosperity.

According to the organizers, California continues to set the pace for green policy, practice, and economic opportunity. In 2011 California set aggressive renewable energy goals requiring that one third of the state?s electricity come from renewable sources. In addition, the state has implemented the first ever carbon-credit auction, and mandated for 1.5 million zero-emission vehicles on its roadways by 2025.

The Green California Summit and Expo, held at the Sacramento Convention Centre is open to the public and is held this week, Thursday April 18^th and Friday April 19^th.

Source: http://www.hybridcars.com/green-cars-showcased-in-sacramento-at-green-california-summit-and-exposition/

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Aubrey Plaza asked to leave MTV Movie Awards

LOS ANGELES (AP) ? Aubrey Plaza interrupted Will Ferrell's acceptance speech at the MTV Movie Awards, then left the building.

MTV officials confirmed Monday that the "Parks and Recreation" actress was asked to leave the ceremony after unexpectedly walking on stage and trying to take Ferrell's trophy as he accepted the Comedic Genius Award.

The irreverent awards show, held Sunday at Sony Pictures Studios, is known for its quirky stunts, but it's unclear whether the actress' stage-crashing move was planned.

"What's happening? Are you OK?" Ferrell asked the actress, who had the name of her new film scrawled across her chest in pen, as she grabbed his trophy with one hand and held a drink with the other.

He held tight to the golden popcorn and the actress returned to her seat in the front row.

"Aubrey Plaza, everyone," Ferrell continued. "Just like we rehearsed it."

Rebel Wilson hosted the ceremony and also won two awards: breakthrough performance and best musical moment for her work in "Pitch Perfect."

"The Avengers" was the night's big winner, taking three awards including movie of the year. "Silver Linings Playbook" also won three awards.

Emma Watson received the Trailblazer Award and Jamie Foxx accepted the Generation Award.

Ferrell was the inaugural recipient of the Comedic Genius Award, and he wore a three-piece suit covered in dollar bills to accept the prize.

"For those of you sitting here tonight who don't think I'm funny, I'll be happy to fight you in the parking lot after the show," he said.

No word on whether Plaza was waiting in the parking lot.

___

Follow AP Entertainment Writer Sandy Cohen: www.twitter.com/APSandy

___

Online:

http://www.mtv.com/ontv/movieawards/2013

Source: http://news.yahoo.com/aubrey-plaza-asked-leave-mtv-movie-awards-174844493.html

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Justin Bieber criticized for hoping Anne Frank would've been a 'belieber'

By Gael Fashingbauer Cooper, TODAY

Singer Justin Bieber stirred controversy over the weekend for claiming that Anne Frank, who wrote movingly of her years spent hiding from the Nazis, might have been a fan of his.

Frazer Harrison / Getty Images

Staff of the Anne Frank House in Amsterdam, where Frank and family hid from the Nazis until they were betrayed in 1944, posted on Facebook that Bieber visited the landmark building.

The staff noted that Bieber signed the museum's guestbook with, "Truly inspiring to be able to come here. Anne was a great girl. Hopefully she would have been a belieber."

Facebook readers were not happy with Bieber's assumption.

"She would've been a WHAT?" wrote Kevin Garcia Leon. "That little idiot is way too full of himself. She's an important historical figure so show some respect."

"Way to turn an inspiring moment into something about yourself," wrote Meghan Mausteller.

According to the Facebook page, fans waited outside the Anne Frank House to see Bieber, who spent an hour in the museum and was in The Netherlands for a concert.

Related content:

Source: http://feeds.nbcnews.com/c/35002/f/653387/s/2ab84d49/l/0Ltodayentertainment0Btoday0N0C0Inews0C20A130C0A40C150C177493490Ejustin0Ebieber0Ecriticized0Efor0Ehoping0Eanne0Efrank0Ewouldve0Ebeen0Ea0Ebelieber0Dlite/story01.htm

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Neighbors move electrons jointly: Ultrafast collective electron transfer after excitation of single electron

Apr. 16, 2013 ? Applying femtosecond x-ray methods, researchers at the Max-Born-Institute in Berlin (Germany) and the Ecole Polytechnique Federale de Lausanne (Switzerland) observed an extremely fast, collective electron transfer of ~100 molecular ions after excitation of a single electron in a crystal of transition metal complexes.

Photochemistry and molecular photovoltaics make frequent use of so-called transition metal complexes which consist of a central metal ion bonded to a group of surrounding ligands. Such materials display a strong absorption of ultraviolet or visible light, making them attractive as primary light absorbers in molecular solar cells and other devices of molecular optoelectronics. Absorption of light is followed by an extremely fast shift of electrons from the metal ion to the ligands, a mechanism that is essential for generating an electric voltage. All applications rely on solid state materials in which transition metal complexes are densely packed and can interact with each other. So far, the influence of this interaction on the very fast electron motions following the absorption of light has remained unclear.

To observe ultrafast electron motions in space and time, one needs to measure the position of electrons in the material with a precision of the order of 0.1 nm (0.1 nm =10^-10 m), roughly corresponding to the distance between neighboring atoms, and on a sub-100 fs time scale (1 fs = 10^-15s). This is possible by imaging the material with extremely short x-ray pulses which are scattered from the electrons and provide their spatial arrangement. The electron motions are initiated by an ultrashort optical pulse which excites an electron on an individual complex.

In the current issue of Journal of Chemical Physics, Benjamin Freyer, Flavio Zamponi, Vincent Juve, Johannes Stingl, Michael Woerner, Thomas Elsaesser and Majed Chergui report the first in-situ x-ray imaging of electron and atom motions induced by such an electron transfer excitation. For the prototype material [Fe(bpy)₃]²⁺(PF₆^-)₂, they show time-dependent 'electron maps' derived from x-ray snapshots taken with 100 fs long hard x-ray flashes. Taking x-ray snapshots at various times during and after the optical pulse that triggers the charge transfer, creates a molecular movie of electron and atom motions.

To the big surprise of the researchers, the time-dependent 'electron maps' reveal a transfer of electronic charge not only from the Fe atoms to the bipyridine units but -- so far unknown -- an even larger amount of electronic charge from the PF₆^- counterions to the bipyridine units. The analysis of the x-ray snapshots shows that the charge transfer affects approximately 30 complexes around the directly photo-excited one. This collective electron response is caused by the electric Coulomb forces between the different ions and minimizes the total electrostatic energy in the crystal. Such behavior is highly favorable for charge collection and injection in optoelectronic devices.

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The above story is reprinted from materials provided by Forschungsverbund Berlin e.V. (FVB).

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Benjamin Freyer, Flavio Zamponi, Vincent Juve?, Johannes Stingl, Michael Woerner, Thomas Elsaesser, Majed Chergui. Ultrafast inter-ionic charge transfer of transition-metal complexes mapped by femtosecond X-ray powder diffraction. The Journal of Chemical Physics, 2013; 138 (14): 144504 DOI: 10.1063/1.4800223

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/mE_NDZiag8M/130416102201.htm

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Sydney Limousine hire for all special occasions | JC Limousines in

Hiring a limo for special occasions has become a trend these days. Seeing the craze many limo companies in Sydney now offer affordable limo services for all events so that everybody can experience to travel in luxury and grandeur.

Cheap limo hire Sydney is available for:

Airport transfers: When traveling for business or leisure; the one thing that bothers all of us is how to reach the airport timely. Peak rush hours, jam packed roads?. Seeing this all reliable Sydney airport Limousine becomes need of an hour.

Corporate travels: When traveling to meeting venues, conferences or seminars; one needs services that can put positive impression on the clients. Corporate Limo services help you vow your clients by offering you with the best services in the area. Uniformed and well mannered chauffeurs, luxury limousines, timely services?. These all strives to make your meeting a success.

Wedding Limousine: Wedding is the most special day in one?s life. This big day needs to be celebrated in a huge manner. Book a Wedding limo to surprise your bride. Soft music, champagne, cake, red carpet, flowers?? all will be arranged to make your wedding an unforgettable memory for you and your guest.

Concerts and sporting events: When planning to go for a concert or a sporting event; nothing can be better than hiring a limo that can comfortably pick and drop you and your group to and from the venue. Stay away from the parking and traffic hassles and be ready to cheer your favourite team or singer.

To book a limo for any of these events; search for Sydney Limos online or else you can find their contact numbers in the local directories. In the online directories you can also read about the company reviews and can also have the other important information.

Make a list of the companies you think are fitting your requirements and then enquire about their packages. Talk to their customer representative and clear all your queries. Select the fleet according to the number of people traveling with you and luggage if any. Also ask them about their license, insurance and registration status. If satisfied book one and give them all proper pick up and drop details.

Sydney Limousine Hire

When in Sydney; you can hire limos with JC Limousines. They offer corporate limo service for all events including weddings, corporate services, airport transfers and fun leisure. Their fleets include Maserati Quattroporate, Stretch Hummers, Stretch Chrysler, Stretch Ford LTD, Stretch Dodge Nitro, Mercedes S Class, BMW 7 series and Audi Q8.

Source: http://www.jclimousines.com.au/blog/?p=204

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Source: http://pekingese-distributions.blogspot.com/2013/04/sydney-limousine-hire-for-all-special.html

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Self-medication in animals much more widespread than believed

Apr. 11, 2013 ? It's been known for decades that animals such as chimpanzees seek out medicinal herbs to treat their diseases. But in recent years, the list of animal pharmacists has grown much longer, and it now appears that the practice of animal self-medication is a lot more widespread than previously thought, according to a University of Michigan ecologist and his colleagues.

Animals use medications to treat various ailments through both learned and innate behaviors. The fact that moths, ants and fruit flies are now known to self-medicate has profound implications for the ecology and evolution of animal hosts and their parasites, according to Mark Hunter, a professor in the Department of Ecology and Evolutionary Biology and at the School of Natural Resources and Environment.

In addition, because plants remain the most promising source of future pharmaceuticals, studies of animal medication may lead the way in discovering new drugs to relieve human suffering, Hunter and two colleagues wrote in a review article titled "Self-Medication in Animals," to be published online today in the journal Science.

"When we watch animals foraging for food in nature, we now have to ask, are they visiting the grocery store or are they visiting the pharmacy?" Hunter said. "We can learn a lot about how to treat parasites and disease by watching other animals."

Much of the work in this field has focused on cases in which animals, such as baboons and woolly bear caterpillars, medicate themselves. One recent study has suggested that house sparrows and finches add high-nicotine cigarette butts to their nests to reduce mite infestations.

But less attention has been given to the many cases in which animals medicate their offspring or other kin, according to Hunter and his colleagues. Wood ants incorporate an antimicrobial resin from conifer trees into their nests, preventing microbial growth in the colony. Parasite-infected monarch butterflies protect their offspring against high levels of parasite growth by laying their eggs on anti-parasitic milkweed.

Hunter and his colleagues suggest that researchers in the field should "de-emphasize the 'self' in self-medication" and base their studies on a more inclusive framework.

"Perhaps the biggest surprise for us was that animals like fruit flies and butterflies can choose food for their offspring that minimizes the impacts of disease in the next generation," Hunter said. "There are strong parallels with the emerging field of epigenetics in humans, where we now understand that dietary choices made by parents influence the long-term health of their children."

The authors argue that animal medication has several major consequences on the ecology and evolution of host-parasite interactions. For one, when animal medication reduces the health of parasites, there should be observable effects on parasite transmission or virulence.

For example, when gypsy moth caterpillars consume foliage high in certain toxic compounds, transmission of viruses between the caterpillars is reduced, facilitating moth outbreaks.

In addition, animal medication should affect the evolution of animal immune systems, according to Hunter and his colleagues. Honeybees are known to incorporate antimicrobial resins into their nests. Analysis of the honeybee genome suggests that they lack many of the immune-system genes of other insects, raising the possibility that honeybees' use of medicine has been partly responsible -- or has compensated -- for a loss of other immune mechanisms.

The authors also note that the study of animal medication will have direct relevance for human food production. Disease problems in agricultural organisms can worsen when humans interfere with the ability of animals to medicate, they point out.

For example, increases in parasitism and disease in honeybees can be linked to selection by beekeepers for reduced resin deposition by their bees. A reintroduction of such behavior in managed bee colonies would likely have great benefits for disease management, the authors say.

The first author of the Science paper is Jacobus de Roode of Emory University. The other author is Thierry Lefevre of the Institut de Recherche pour le Developpement in France.

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The above story is reprinted from materials provided by University of Michigan.

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Journal Reference:

1. J. C. de Roode, T. Lefevre, M. D. Hunter. Self-Medication in Animals. Science, 2013; 340 (6129): 150 DOI: 10.1126/science.1235824

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/j2v2-vYpJtc/130411142716.htm

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Deal of the Day: 52% off BodyGuardz UltraTough Clear Full Body for iPhone 5

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Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/hej_3FM4Oro/story01.htm

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New drug target companion prognostic test for hormone therapy resistance

Apr. 1, 2013 ? A team of international cancer researchers led by Dr. Mathieu Lupien at the Princess Margaret Cancer Centre, University Health Network, has identified the signalling pathway that is over-activated in estrogen receptor (ER)-positive breast cancer cells that are resistant to hormone therapies such as tamoxifen, aromatase inhibitors or fulvestrant.

Resistance to hormone therapy is reported in almost half of ER-positive breast cancer patients and no cure is currently available. The fact that the pathway, called Notch, is a drug target creates hope for a new therapy.

The findings, published online today in the Proceedings of the National Academy of Sciences, "provide a new therapeutic target against hormone therapy-resistant breast cancers and a companion test to identify tumours that would become resistant" says Dr. Lupien, a scientist at the Ontario Cancer Institute, the research arm of the cancer centre, and an Assistant Professor in the Department of Medial Biophysics, University of Toronto. He specializes in epigenetics of hormone-dependent cancers -- the study of non-genetic determinants of cellular identity that can also be altered to initiate or modify disease.

"In studying the epigenetics of hormone therapy resistance, we discovered that breast cancer cells behave like a chameleon. Indeed, as the chameleon changes its skin colour to camouflage itself and evade predators," says Dr. Lupien, "breast cancer cells change the appearance of their DNA through epigenetics to evade, in this case, hormone therapy." In so doing, hormone therapy-resistant breast cancer cells highlight regions of their DNA related to the Notch pathway.

At the molecular level, the research team characterized the epigenetic appearances of the DNA of drug-resistant and drug-responsive breast cancer cells. The team discovered that the Notch signaling pathway plays the predominant role in drug-resistant breast cancer cells even if cells remain positive for ER.

"This is a highly promising discovery that could rapidly translate in the clinic. Drugs against the Notch pathway are available." says Dr. Lupien. The key will be to test the efficacy of these drugs against hormone therapy resistance in breast cancer.

The research was funded by the National Cancer Institute, the American Cancer Society and the Ontario Institute for Cancer Research. Dr. Lupien's research is also supported by The Princess Margaret Cancer Foundation.

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Journal Reference:

1. Luca Magnani, Alexander Stoeck, Xiaoyang Zhang, Andr?s L?nczky, Anne C. Mirabella, Tian-Li Wang, Bal?zs Gyorffy, and Mathieu Lupien. Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1219992110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/pUzj0i7pl44/130401151035.htm

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